● Supports antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, hepato-protective, immunomodulatory, and anti-rheumatic effects (123).
● Reduces inflammation via decreases of inflammatory markers such as c-reactive protein, interleukin 6, tumor necrosis factor, and decreased cytokine production (123).
● Supports joint health via decreases in connective tissue inflammation and improved pain in individuals with osteoarthritis (122).
● Supports blood sugar regulation via increased pancreatic beta cell function and improved insulin sensitivity (121).
● Supports cardiovascular and liver health via reduced accumulation of advanced glycation end products (AGE), reduced lipid peroxidation, and improved vascular function.
● Curcumin exhibits an antioxidant activity via scavenging of superoxide anion (∙O2−∙) and hydroxyl radicals (∙OH) (scavenging of inflammation molecules) (118,119).
● Curcumin modulates breast carcinogenesis through its effect on cell cycle and proliferation, apoptosis, senescence, cancer spread and angiogenesis (119).
● Curcumin targets cancer growth pathways such as the NFkB, PI3K/Akt/mTOR, MAPK and JAK/STAT. thereby suppressing tumor growth (119).
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